Cleveland Cavaliers 2021-22 NBA Regular Season is scheduled to start with a basketball game against the Memphis Grizzlies Wednesday, October 20, 2021, at FedExForum, Memphis, Tennessee, and end with a game against the Milwaukee Bucks Sunday, April 10, 2022, at Rocket Mortgage Fieldhouse, Cleveland, Ohio.
Here is the Cavaliers NBA basketball game schedule, start time, date, location, TV channel, and current results you need to know.
| Opponent | Time (ET) | Date | Venue | TV |
| Grizzlies | 8:00 PM | Wed, Oct 20 | FedExForum | Bally Sports Ohio |
| Hornets | 7:00 PM | Fri, Oct 22 | Rocket Mortgage Fieldhouse | Bally Sports Ohio |
| Hawks | 6:00 PM | Sat, Oct 23 | Rocket Mortgage Fieldhouse | Bally Sports Ohio |
| Nuggets | 9:00 PM | Mon, Oct 25 | Ball Arena | Bally Sports Ohio |
| Clippers | 10:30 PM | Wed, Oct 27 | Staples Center | Bally Sports Ohio |
| Lakers | 10:30 PM | Fri, Oct 29 | Staples Center | Bally Sports Ohio |
| Suns | 10:00 PM | Sat, Oct 30 | Footprint Center | Bally Sports Ohio |
| Hornets | 7:00 PM | Mon, Nov 1 | Spectrum Center | Bally Sports Ohio |
| Trail Blazers | 7:00 PM | Wed, Nov 3 | Rocket Mortgage Fieldhouse | Bally Sports Ohio |
| Raptors | 7:30 PM | Fri, Nov 5 | Scotiabank Arena | Bally Sports Ohio |
| Knicks | 6:00 PM | Sun, Nov 7 | Madison Square Garden | Bally Sports Ohio |