Portland Trail Blazers 2021-22 NBA Regular Season is scheduled to start with a basketball game against the Sacramento Kings Wednesday, October 20, 2021, at Moda Center at the Rose Quarter, Portland, Oregon and end with a game against the Utah Jazz Sunday, April 10, 2022, at Moda Center at the Rose Quarter, Portland, Oregon.
Here is the Trail Blazers NBA basketball game schedule, start time, date, location, TV channel, and current results you need to know.
| Opponent | Time (ET) | Date | Venue | TV |
| Kings | 10:00 PM | Wed, Oct 20 | Moda Center at the Rose Quarter | Root Sports |
| Suns | 10:00 PM | Sat, Oct 23 | Moda Center at the Rose Quarter | NBA TV |
| Clippers | 10:30 PM | Mon, Oct 25 | Staples Center | NBA TV |
| Grizzlies | 10:00 PM | Wed, Oct 27 | Moda Center at the Rose Quarter | ESPN |
| Clippers | 10:00 PM | Fri, Oct 29 | Moda Center at the Rose Quarter | Root Sports |
| Hornets | 7:00 PM | Sun, Oct 31 | Spectrum Center | Root Sports |
| 76ers | 7:00 PM | Mon, Nov 1 | Wells Fargo Center | Root Sports |
| Cavaliers | 7:00 PM | Wed, Nov 3 | Rocket Mortgage Fieldhouse | Root Sports |
| Pacers | 10:00 PM | Fri, Nov 5 | Moda Center at the Rose Quarter | Root Sports |
| Lakers | 10:30 PM | Sat, Nov 6 | Moda Center at the Rose Quarter | NBA TV |
| Clippers | 10:00 PM | Tue, Nov 9 | Staples Center | TNT |
| Suns | 9:00 PM | Wed, Nov 10 | Footprint Center | Root Sports |
| Rockets | 8:00 PM | Fri, Nov 12 | Toyota Center | Root Sports |
| Nuggets | 8:00 PM | Sun, Nov 14 | Ball Arena | Root Sports |
| Raptors | 10:00 PM | Mon, Nov 15 | Moda Center at the Rose Quarter | Root Sports |