| Date | Matchups | TV |
| November 5, 2021 | Memphis Hustle 90 at Mexico City Capitanes 95 | TBD |
| November 7, 2021 | Memphis Hustle 110 at Mexico City Capitanes 106 | TBD |
| November 16, 2021 | Texas Legends 100 at Memphis Hustle 106 | TBD |
| November 18, 2021 | Texas Legends 115 at Memphis Hustle 99 | TBD |
| November 26, 2021 | Memphis Hustle 103 at Austin Spurs 94 | TBD |
| November 27, 2021 | Memphis Hustle 108 at Austin Spurs 78 | TBD |
| December 3, 2021 | Lakeland Magic 118 at Memphis Hustle 97 | TBD |
| December 5, 2021 | Lakeland Magic 119 at Memphis Hustle 100 | TBD |
| December 7, 2021 | Rio Grande Valley Vipers 92 at Memphis Hustle 116 | TBD |
| December 9, 2021 | Rio Grande Valley Vipers 117 at Memphis Hustle 121 | TBD |
| December 13, 2021 | Memphis Hustle 97 at Birmingham Squadron 119 | TBD |
| December 14, 2021 | Memphis Hustle 109 at Birmingham Squadron 113 | TBD |
| December 19, 2021 | College Park Skyhawks 134 at Memphis Hustle 130 (Las Vegas) | TBD |
| December 20, 2021 | Memphis Hustle 118 at Greensboro Swarm 122 (Las Vegas) | TBD |
| December 30, 2021 | Memphis Hustle at Rio Grande Valley Vipers | TBD |
| January 2, 2022 | Agua Caliente Clippers of Ontario at Memphis Hustle | TBD |
| January 3, 2022 | Texas Legends at Memphis Hustle | TBD |
| January 10, 2022 | Santa Cruz Warriors 132 at Memphis Hustle 130 | TBD |
| January 13, 2022 | Memphis Hustle 102 at Iowa Wolves 117 | TBD |
| January 15, 2022 | Memphis Hustle 113 at Sioux Falls Skyforce 105 | TBD |
| January 16, 2022 | Memphis Hustle 107 at Sioux Falls Skyforce 99 | TBD |
| January 18, 2022 | Memphis Hustle 106 at Salt Lake City Stars 117 | TBD |
| January 19, 2022 | Memphis Hustle 98 at Salt Lake City Stars 120 | TBD |
| January 21, 2022 | Memphis Hustle 107 at Austin Spurs 114 | TBD |
| January 24, 2022 | South Bay Lakers 124 at Memphis Hustle 116 | TBD |
| January 26, 2022 | South Bay Lakers 127 at Memphis Hustle 124 | TBD |
| February 2, 2022 | Iowa Wolves 103 at Memphis Hustle 111 | TBD |
| February 4, 2022 | Birmingham Squadron 129 at Memphis Hustle 116 | TBD |
| February 6, 2022 | Memphis Hustle 110 at Texas Legends 97 | TBD |
| February 8, 2022 | Memphis Hustle 110 at Birmingham Squadron 122 | TBD |
| February 10, 2022 | Iowa Wolves 111 at Memphis Hustle 106 | TBD |
| February 13, 2022 | Oklahoma City Blue 97 at Memphis Hustle 104 | TBD |
| February 14, 2022 | Oklahoma City Blue 116 at Memphis Hustle 87 | TBD |
| February 17, 2022 | Stockton Kings 114 at Memphis Hustle 121 | TBD |
| February 23, 2022 | Austin Spurs 142 at Memphis Hustle 116 | TBD |
| February 25, 2022 | Austin Spurs 114 at Memphis Hustle 105 | TBD |
| February 26, 2022 | Sioux Falls Skyforce 101 at Memphis Hustle 96 | TBD |
| March 2, 2022 | Memphis Hustle 114 at Oklahoma City Blue 109 | TBD |
| March 4, 2022 | Memphis Hustle 117 at Santa Cruz Warriors 120 | TBD |
| March 5, 2022 | Memphis Hustle 107 at Santa Cruz Warriors 99 | TBD |
| March 8, 2022 | Memphis Hustle 106 at Stockton Kings 98 | TBD |
| March 10, 2022 | Memphis Hustle 119 at South Bay Lakers 129 | TBD |
| March 12, 2022 | Memphis Hustle 116 at Agua Caliente Clippers of Ontario 104 | TBD |
| March 13, 2022 | Memphis Hustle 118 at Agua Caliente Clippers of Ontario 114 | TBD |
| March 16, 2022 | Salt Lake City Stars 112 at Memphis Hustle 124 | TBD |
| March 19, 2022 | Memphis Hustle 139 at Rio Grande Valley Vipers 131 | TBD |
| March 21, 2022 | Memphis Hustle 128 at Rio Grande Valley Vipers 126 | TBD |
| March 25, 2022 | Memphis Hustle 112 at Texas Legends 121 | TBD |
| March 28, 2022 | Rio Grande Valley Vipers 128 at Memphis Hustle 115 | TBD |
| March 29, 2022 | Stockton Kings 115 at Memphis Hustle 123 | TBD |
| April 2, 2022 | Birmingham Squadron 126 at Memphis Hustle 111 | TBD |
